Significance of lipids, lipoproteins, and apolipoproteins during the first 14-16 months of life.
Eur Heart J
; 44(42): 4408-4418, 2023 11 07.
Article
en En
| MEDLINE
| ID: mdl-37632410
ABSTRACT
BACKGROUND AND AIMS:
The aims of this study were to investigate lipid parameters during the first 14-16 months of life, to identify influential factors, and to test whether high concentrations at birth predict high concentrations at 2- and 14-16 months.METHODS:
The Copenhagen Baby Heart Study, including 13,354 umbilical cord blood samples and parallel venous blood samples from children and parents at birth (n = 444), 2 months (n = 364), and 14-16 months (n = 168), was used.RESULTS:
Concentrations of lipids, lipoproteins, and apolipoproteins in umbilical cord blood samples correlated highly with venous blood samples from newborns. Concentrations of low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, apolipoprotein B, and lipoprotein(a) increased stepwise from birth to 2 months to 14-16 months. Linear mixed models showed that concentrations of LDL cholesterol, non-HDL cholesterol, and lipoprotein(a) above the 80th percentile at birth were associated with significantly higher concentrations at 2 and 14-16 months. Finally, lipid concentrations differed according to sex, gestational age, birth weight, breastfeeding, and parental lipid concentrations.CONCLUSIONS:
Lipid parameters changed during the first 14-16 months of life, and sex, gestational age, birth weight, breastfeeding, and high parental concentrations influenced concentrations. Children with high concentrations of atherogenic lipid traits at birth had higher concentrations at 2 and 14-16 months. These findings increase our knowledge of how lipid traits develop over the first 14-16 months of life and may help in deciding the optimal child age for universal familial hypercholesterolaemia screening.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apolipoproteínas
/
Lípidos
Tipo de estudio:
Prognostic_studies
Límite:
Child
/
Humans
/
Newborn
Idioma:
En
Revista:
Eur Heart J
Año:
2023
Tipo del documento:
Article
País de afiliación:
Dinamarca