Effects of sleep fragmentation on white matter pathology in a rat model of cerebral small vessel disease.
Sleep
; 47(4)2024 Apr 12.
Article
en En
| MEDLINE
| ID: mdl-37638817
ABSTRACT
STUDY OBJECTIVES:
Mounting evidence indicated the correlation between sleep and cerebral small vessel disease (CSVD). However, little is known about the exact causality between poor sleep and white matter injury, a typical signature of CSVD, as well as the underlying mechanisms.METHODS:
Spontaneously hypertensive rats (SHR) and control Wistar Kyoto rats were subjected to sleep fragmentation (SF) for 16 weeks. The effects of chronic sleep disruption on the deep white matter and cognitive performance were observed.RESULTS:
SHR were validated as a rat model for CSVD. Fragmented sleep induced strain-dependent white matter abnormalities, characterized by reduced myelin integrity, impaired oligodendrocytes precursor cells (OPC) maturation and pro-inflammatory microglial polarization. Partially reversible phenotypes of OPC and microglia were observed in parallel following sleep recovery.CONCLUSIONS:
Long-term SF-induced pathological effects on the deep white matter in a rat model of CSVD. The pro-inflammatory microglial activation and the block of OPC maturation may be involved in the mechanisms linking sleep to white matter injury.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades de los Pequeños Vasos Cerebrales
/
Sustancia Blanca
Límite:
Animals
Idioma:
En
Revista:
Sleep
Año:
2024
Tipo del documento:
Article
País de afiliación:
China