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Management of Hepatitis C Virus and Hepatitis B Virus Infection in the Setting of Kidney Disease.
Sharma, Purva; Sawtell, Rani; Wang, Qiyu; Sise, Meghan E.
Afiliación
  • Sharma P; Department of Medicine, Division of Nephrology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell; Glomerular Disease Center at Northwell Health, Hempstead, NY.
  • Sawtell R; Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA.
  • Wang Q; Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA.
  • Sise ME; Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA. Electronic address: msise@partners.org.
Adv Kidney Dis Health ; 30(4): 343-355, 2023 07.
Article en En | MEDLINE | ID: mdl-37657881
Treatment of chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infection poses unique challenges in patients with kidney disease. Direct-acting antivirals have been a major breakthrough in eradicating HCV infection, and several pangenotypic regimens are available for patients with chronic kidney disease or end-stage kidney disease requiring dialysis with high cure rates and no need for dose adjustment. Direct-acting antiviral therapy alone can treat HCV-associated cryoglobulinemic glomerulonephritis; concurrent antiviral and immunosuppressive therapy is needed for cases of severe, organ-threatening manifestations of cryoglobulinemia. Immunosuppression may be needed for HBV-associated kidney disease (polyarteritis nodosa or membranous nephropathy) when there is evidence of severe immune-mediated injury while weighing the risk of potential viral activation. Most HBV antiviral agents need to be dose-adjusted in patients with chronic kidney disease or end-stage kidney disease requiring dialysis, and drug-drug interactions need to be carefully evaluated in patients with kidney transplants. Considerations for accepting HCV- and HBV-infected donors for kidney transplantation are discussed.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hepatitis C / Hepatitis C Crónica / Insuficiencia Renal Crónica / Hepatitis B / Fallo Renal Crónico Límite: Humans Idioma: En Revista: Adv Kidney Dis Health Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Hepatitis C / Hepatitis C Crónica / Insuficiencia Renal Crónica / Hepatitis B / Fallo Renal Crónico Límite: Humans Idioma: En Revista: Adv Kidney Dis Health Año: 2023 Tipo del documento: Article