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Determination of Pentachlorophenol in Seafood Samples from Zhejiang Province Using Pass-Through SPE-UPLC-MS/MS: Occurrence and Human Dietary Exposure Risk.
Yan, Xiaoyang; Zhao, Qiaoling; Yan, Zhongyong; Chen, Xuechang; He, Pengfei; Li, Shiyan; Fang, Yi.
Afiliación
  • Yan X; School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.
  • Zhao Q; Key Laboratory of Sustainable Utilization of Technology Research for Fisheries Resources of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, Zhoushan 316021, China.
  • Yan Z; Zhoushan Institute for Food and Drug Control, Zhoushan 316012, China.
  • Chen X; Zhejiang Marine Ecology and Environment Monitoring Center, Zhoushan 316021, China.
  • He P; Key Laboratory of Sustainable Utilization of Technology Research for Fisheries Resources of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, Zhoushan 316021, China.
  • Li S; Key Laboratory of Sustainable Utilization of Technology Research for Fisheries Resources of Zhejiang Province, Zhejiang Marine Fisheries Research Institute, Zhoushan 316021, China.
  • Fang Y; Zhejiang Fisheries Technology Extension Center, Hangzhou 310023, China.
Molecules ; 28(17)2023 Sep 01.
Article en En | MEDLINE | ID: mdl-37687223
Pentachlorophenol (PCP) has attracted wide attention due to its high toxicity, persistence, and bioaccumulation. In this study, a sensitive UPLC-MS/MS method for the determination of PCP in seafood samples was developed and validated. The samples were ultrasonic extracted with acetonitrile containing 1% acetic acid-acetonitrile and followed by using a pass-through solid-phase extraction (SPE) cleanup on Captiva EMR-Lipid cartridges. The linearity of this method ranged from 1 to 1000 µg/L, with regression coefficients of >0.99. The detection limit and quantitation limit were 0.5 µg/kg and 1.0 µg/kg, respectively. The recoveries in different types of seafood samples ranged from 86.4% to 102.5%, and the intra-day and inter-day relative standard deviations (RSDs) were 3.7% to 11.2% and 2.9% to 12.1%, respectively (n = 6). Finally, the method has been successfully utilized for the screening of PCP in 760 seafood samples from Zhejiang Province. PCP was detected in 5.8% of all seafood samples, with the largest portion of detections found in shellfish, accounting for approximately 60% of the total. The average concentrations detected ranged from 1.08 to 21.49 µg/kg. The non-carcinogenic risk indices for adults and children who consume PCP ranged from 10-4 to 10-3 magnitudes. All of these indices stayed significantly below 1, implying that the health risk from PCP in marine organisms to humans is minimal.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pentaclorofenol Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pentaclorofenol Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China