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Hydrogen-Bonded Organic Frameworks Chelated Manganese for Precise Magnetic Resonance Imaging Diagnosis of Cancers.
Ouyang, Sixue; Chen, Chuyao; Lin, Peiru; Wu, Wanjia; Chen, Guanjun; Li, Pengfei; Sun, Mingyan; Chen, Huiting; Zheng, Zhiyuan; You, Yuanyuan; Lv, Sike; Zhao, Peng; Lin, Bingquan; Tao, Jia.
Afiliación
  • Ouyang S; School of Chemistry and Chemical Engineering, South China University of Technology, 510640 Guangzhou, China.
  • Chen C; Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China.
  • Lin P; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
  • Wu W; Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China.
  • Chen G; Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China.
  • Li P; Cancer Center, MD TCM-integrated Hospital, Southern Medical University, 510515 Guangzhou, China.
  • Sun M; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
  • Chen H; School of Chemistry and Chemical Engineering, South China University of Technology, 510640 Guangzhou, China.
  • Zheng Z; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
  • You Y; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
  • Lv S; School of Chemistry and Chemical Engineering, South China University of Technology, 510640 Guangzhou, China.
  • Zhao P; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 510515 Guangzhou, China.
  • Lin B; Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China.
  • Tao J; School of Chemistry and Chemical Engineering, South China University of Technology, 510640 Guangzhou, China.
Nano Lett ; 23(18): 8628-8636, 2023 09 27.
Article en En | MEDLINE | ID: mdl-37694968
ABSTRACT
Magnetic resonance imaging (MRI) is an important tool in the diagnosis of many cancers. However, clinical gadolinium (Gd)-based MRI contrast agents have limitations, such as large doses and potential side effects. To address these issues, we developed a hydrogen-bonded organic framework-based MRI contrast agent (PFC-73-Mn). Due to the hydrogen-bonded interaction of water molecules and the restricted rotation of manganese ions, PFC-73-Mn exhibits high longitudinal relaxation r1 (5.03 mM-1 s-1) under a 3.0 T clinical MRI scanner. A smaller intravenous dose (8 µmol of Mn/kg) of PFC-73-Mn can provide strong contrast and accurate diagnosis in multiple kinds of cancers, including breast tumor and ultrasmall orthotopic glioma. PFC-73-Mn represents a prospective new approach in tumor imaging, especially in early-stage cancer.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glioma / Manganeso Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Nano Lett Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glioma / Manganeso Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Nano Lett Año: 2023 Tipo del documento: Article País de afiliación: China