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Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas.
Herrgott, Grayson A; Snyder, James M; She, Ruicong; Malta, Tathiane M; Sabedot, Thais S; Lee, Ian Y; Pawloski, Jacob; Podolsky-Gondim, Guilherme G; Asmaro, Karam P; Zhang, Jiaqi; Cannella, Cara E; Nelson, Kevin; Thomas, Bartow; deCarvalho, Ana C; Hasselbach, Laura A; Tundo, Kelly M; Newaz, Rehnuma; Transou, Andrea; Morosini, Natalia; Francisco, Victor; Poisson, Laila M; Chitale, Dhananjay; Mukherjee, Abir; Mosella, Maritza S; Robin, Adam M; Walbert, Tobias; Rosenblum, Mark; Mikkelsen, Tom; Kalkanis, Steven; Tirapelli, Daniela P C; Weisenberger, Daniel J; Carlotti, Carlos G; Rock, Jack; Castro, Ana Valeria; Noushmehr, Houtan.
Afiliación
  • Herrgott GA; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Snyder JM; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • She R; Department of Public Health, Biostatistics, Henry Ford Health, Detroit, MI, USA.
  • Malta TM; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Sabedot TS; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Lee IY; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Pawloski J; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Podolsky-Gondim GG; Department of Neurosurgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
  • Asmaro KP; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Zhang J; Department of Public Health, Biostatistics, Henry Ford Health, Detroit, MI, USA.
  • Cannella CE; Department of Public Health, Biostatistics, Henry Ford Health, Detroit, MI, USA.
  • Nelson K; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Thomas B; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • deCarvalho AC; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Hasselbach LA; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Tundo KM; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Newaz R; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Transou A; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Morosini N; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Francisco V; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Poisson LM; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Chitale D; Department of Public Health, Biostatistics, Henry Ford Health, Detroit, MI, USA.
  • Mukherjee A; Department of Pathology, Henry Ford Health, Detroit, MI, USA.
  • Mosella MS; Department of Pathology, Henry Ford Health, Detroit, MI, USA.
  • Robin AM; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Walbert T; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Rosenblum M; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Mikkelsen T; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Kalkanis S; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Tirapelli DPC; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Weisenberger DJ; Department of Neurosurgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
  • Carlotti CG; Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
  • Rock J; Department of Neurosurgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
  • Castro AV; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA.
  • Noushmehr H; Department of Neurosurgery, Omics Laboratory, Hermelin Brain Tumor Center, Henry Ford Health, Detroit, MI, USA. acastro1@hfhs.org.
Nat Commun ; 14(1): 5669, 2023 09 13.
Article en En | MEDLINE | ID: mdl-37704607
Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification of patients likely to recur using noninvasive approaches could inform treatment strategy, whether intervention or monitoring. In this study, we analyze the DNA methylation levels in blood (serum and plasma) and tissue samples from 155 meningioma patients, compared to other central nervous system tumor and non-tumor entities. We discover DNA methylation markers unique to meningiomas and use artificial intelligence to create accurate and universal models for identifying and predicting meningioma recurrence, using either blood or tissue samples. Here we show that liquid biopsy is a potential noninvasive and reliable tool for diagnosing and predicting outcomes in meningioma patients. This approach can improve personalized management strategies for these patients.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Meníngeas / Meningioma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Meníngeas / Meningioma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos