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Diagnostic value of plasma SIRT1 levels and whole-brain gray matter volume in Parkinson's disease patients with cognitive impairment.
Li, Xiaohuan; Yang, Dawei; Ma, Jianjun; Wei, Wei; Zheng, Jinhua; Fan, Yongyan; Liang, Keke; Shi, Xiaoxue; Li, Dongsheng; She, Zonghan; Qi, Xuelin; Chen, Siyuan.
Afiliación
  • Li X; Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, China.
  • Yang D; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, China.
  • Ma J; Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, China.
  • Wei W; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, China.
  • Zheng J; Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, China. majj1124@163.com.
  • Fan Y; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, China. majj1124@163.com.
  • Liang K; Department of Neurology, Henan University People's Hospital, Zhengzhou, China. majj1124@163.com.
  • Shi X; Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, China.
  • Li D; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, China.
  • She Z; Department of Neurology, Henan University People's Hospital, Zhengzhou, China.
  • Qi X; Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou, China.
  • Chen S; Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, China.
Neurol Sci ; 45(1): 47-54, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37718350
OBJECTIVE: This study was designed to investigate the diagnostic value of plasma SIRT1 levels and whole-brain gray matter (GM) volume in Parkinson's disease (PD) patients with cognitive impairment. METHODS: Automated enzymatic analysis was performed to measure plasma SIRT1 levels in 80 healthy controls and 77 PD patients. Motor symptoms and nonmotor symptoms in PD patients were assessed using the corresponding scales. A Siemens MAGNETOM Prisma 3 T MRI scanner was used to acquire images in 35 of 77 PD patients. RESULTS: Plasma SIRT1 levels in PD patients were lower than those in healthy controls. Plasma SIRT1 levels were negatively correlated with the age, Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) scores, anxiety, depression, excessive daytime sleepiness (EDS), quality of life, and especially cognitive impairment. Thus, it showed that plasma SIRT1 levels were relevant to visuospatial/executive function, memory, and language. Receiver-operating characteristic (ROC) analysis confirmed that plasma SIRT1 levels had good diagnostic accuracy for PD with anxiety and EDS. Furthermore, plasma SIRT1 levels had a significant positive correlation with GM volume in the whole brain, and ROC analysis confirmed that plasma SIRT1 levels and the total GM volume had good diagnostic accuracy for PD with cognitive impairment. CONCLUSIONS: This study showed that plasma SIRT1 levels were correlated with the nonmotor symptoms of anxiety, depression, EDS, and especially cognitive impairment as well as the total GM volume. Furthermore, the combination of plasma SIRT1 levels and the total GM volume had good diagnostic accuracy for PD with cognitive impairment.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Disfunción Cognitiva / Trastornos de Somnolencia Excesiva Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Disfunción Cognitiva / Trastornos de Somnolencia Excesiva Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China