Emerging Roles of Using Small Extracellular Vesicles as an Anti-Cancer Drug.
Int J Mol Sci
; 24(18)2023 Sep 14.
Article
en En
| MEDLINE
| ID: mdl-37762393
ABSTRACT
Small extracellular vesicles (sEVs) are emerging as a novel therapeutic strategy for cancer therapy. Tumor-cell-derived sEVs contain biomolecules that can be utilized for cancer diagnosis. sEVs can directly exert tumor-killing effects or modulate the tumor microenvironment, leading to anti-cancer effects. In this review, the application of sEVs as a diagnostic tool, drug delivery system, and active pharmaceutical ingredient for cancer therapy will be highlighted. The therapeutic efficacies of sEVs will be compared to conventional immune checkpoint inhibitors. Additionally, this review will provide strategies for sEV engineering to enhance the therapeutic efficacies of sEVs. As a bench-to-bedside application, we will discuss approaches to encourage good-manufacturing-practice-compliant industrial-scale manufacturing and purification of sEVs.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vesículas Extracelulares
/
Antineoplásicos
Idioma:
En
Revista:
Int J Mol Sci
Año:
2023
Tipo del documento:
Article