MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib.

Jonas, Katharina; Prinz, Felix; Ferracin, Manuela; Krajina, Katarina; Pasculli, Barbara; Deutsch, Alexander; Madl, Tobias; Rinner, Beate; Slaby, Ondrej; Klec, Christiane; Pichler, Martin

Jonas, Katharina; Prinz, Felix; Ferracin, Manuela; Krajina, Katarina; Pasculli, Barbara; Deutsch, Alexander; Madl, Tobias; Rinner, Beate; Slaby, Ondrej; Klec, Christiane; Pichler, Martin.

Afiliación

Jonas K; Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Prinz F; Research Unit for Non-Coding RNA and Genome Editing in Cancer, Medical University of Graz, Graz, Austria.
Ferracin M; Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Krajina K; Research Unit for Non-Coding RNA and Genome Editing in Cancer, Medical University of Graz, Graz, Austria.
Pasculli B; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Deutsch A; Translational Oncology, II. Med Clinics Hematology and Oncology, Augsburg, Germany.
Madl T; Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia, San Giovanni Rotondo, FG, Italy.
Rinner B; Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Slaby O; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Klec C; BioTechMed-Graz, Graz, Austria.
Pichler M; Department for Biomedical Research, Medical University of Graz, Graz, Austria.

Breast Cancer Res ; 25(1): 119, 2023 10 06.

Article en En | MEDLINE | ID: mdl-37803350

Asunto(s)

MicroARNs; Neoplasias de la Mama Triple Negativas; Humanos; MicroARNs/genética; MicroARNs/metabolismo; Neoplasias de la Mama Triple Negativas/tratamiento farmacológico; Neoplasias de la Mama Triple Negativas/genética; Neoplasias de la Mama Triple Negativas/metabolismo; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Línea Celular Tumoral; Proliferación Celular/genética; Movimiento Celular/genética; Regulación Neoplásica de la Expresión Génica

Palabras clave

AKT signaling; Capivasertib; Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma (PIP5K1C); Triple negative breast cancer (TNBC); microRNA (miRNA)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: MicroARNs / Neoplasias de la Mama Triple Negativas Límite: Humans Idioma: En Revista: Breast Cancer Res Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Austria

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