Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis.
Orthop Surg
; 15(12): 3015-3025, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-37803912
ABSTRACT
The etiology of intervertebral disc degeneration (IDD) and osteoarthritis (OA) is complex and multifactorial. Both predisposing genes and environmental factors are involved in the pathogenesis of IDD and OA. Moreover, epigenetic modifications affect the development of IDD and OA. Dysregulated phenotypes of nucleus pulposus (NP) cells and OA chondrocytes, including apoptosis, extracellular matrix disruption, inflammation, and angiogenesis, are involved at all developmental stages of IDD and OA. RNA binding proteins (RBPs) have recently been recognized as essential post-transcriptional regulators of gene expression. RBPs are implicated in many cellular processes, such as proliferation, differentiation, and apoptosis. Recently, several RBPs have been reported to be associated with the pathogenesis of IDD and OA. This review briefly summarizes the current knowledge on the RNA-regulatory networks controlled by RBPs and their potential roles in the pathogenesis of IDD and OA. These initial findings support the idea that specific modulation of RBPs represents a promising approach for managing IDD and OA.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Osteoartritis
/
MicroARNs
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Degeneración del Disco Intervertebral
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Núcleo Pulposo
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Disco Intervertebral
Límite:
Humans
Idioma:
En
Revista:
Orthop Surg
Año:
2023
Tipo del documento:
Article
País de afiliación:
China