The effect of photobiomodulation on hearing loss: A systematic review.
Clin Otolaryngol
; 49(1): 41-61, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-37885344
ABSTRACT
OBJECTIVES:
To assess outcomes associated with photobiomodulation therapy (PBMT) for hearing loss in human and animal studies.DESIGN:
Systematic review and narrative synthesis in accordance with PRISMA guidelines.SETTING:
Data bases searched MEDLINE, EMBASE, CENTRAL, ClinicalTrials.gov and Web of Science. No limits were placed on language or year of publication. Review conducted in accordance with the PRISMA 2020 statement.PARTICIPANTS:
All human and animal subjects treated with PBMT for hearing loss. MAIN OUTCOMEMEASURES:
Pre- and post-PBMT audio metric outcomes.RESULTS:
Searches identified 122 abstracts and 49 full text articles. Of these, 17 studies met the inclusion criteria, reporting outcomes in 327 animals (11 studies), 30 humans (1 study), and 40 animal specimens (5 studies). PBMT parameters included 6 different wavelengths 908 nm (1 study), 810 nm (1 study), 532 & 635 nm (1 study), 830 nm (3 studies), 808 nm (11 studies). The duration ranged from 4 to 60 minutes in a session, and the follow-up ranged from 5-28 days. Outcomes improved significantly when wavelengths within the range of 800-830 nm were used, and with greater duration of PBMT exposure. Included studies predominantly consisted of non-randomized controlled trials (10 studies).CONCLUSIONS:
Hearing outcomes following PBMT appear to be superior to no PBMT for subjects with hearing loss, although higher level evidence is required to verify this. PBMT enables concentrated, focused delivery of light therapy to the inner ear through a non-invasive manner with minimal side effects. As a result of heterogeneity in reporting PBMT parameters and outcomes across the included studies, direct comparison is challenging.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Terapia por Luz de Baja Intensidad
/
Pérdida Auditiva
Tipo de estudio:
Systematic_reviews
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Otolaryngol
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido