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Advances in regulating vitamin K2 production through metabolic engineering strategies.
Liu, Yan; Wang, Jian; Huang, Jun-Bao; Li, Xiang-Fei; Chen, Yu; Liu, Kun; Zhao, Ming; Huang, Xi-Lin; Gao, Xu-Li; Luo, Ya-Ni; Tao, Wei; Wu, Jing; Xue, Zheng-Lian.
Afiliación
  • Liu Y; College of Biology and Food Engineering, Anhui Polytechnic University, 241000, Wuhu, China. liuyan@ahpu.edu.cn.
  • Wang J; Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, 241000, Wuhu, China. liuyan@ahpu.edu.cn.
  • Huang JB; College of Biology and Food Engineering, Anhui Polytechnic University, 241000, Wuhu, China.
  • Li XF; College of Biology and Food Engineering, Anhui Polytechnic University, 241000, Wuhu, China.
  • Chen Y; College of Biology and Food Engineering, Anhui Polytechnic University, 241000, Wuhu, China.
  • Liu K; Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, 241000, Wuhu, China.
  • Zhao M; College of Biology and Food Engineering, Anhui Polytechnic University, 241000, Wuhu, China.
  • Huang XL; Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, 241000, Wuhu, China.
  • Gao XL; College of Biology and Food Engineering, Anhui Polytechnic University, 241000, Wuhu, China.
  • Luo YN; Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, 241000, Wuhu, China.
  • Tao W; College of Biology and Food Engineering, Anhui Polytechnic University, 241000, Wuhu, China. zhaom@mail.ahpu.edu.cn.
  • Wu J; Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, 241000, Wuhu, China. zhaom@mail.ahpu.edu.cn.
  • Xue ZL; College of Biology and Food Engineering, Anhui Polytechnic University, 241000, Wuhu, China.
World J Microbiol Biotechnol ; 40(1): 8, 2023 Nov 08.
Article en En | MEDLINE | ID: mdl-37938463
Vitamin K2 (menaquinone, VK2, MK) is an essential lipid-soluble vitamin that plays critical roles in inhibiting cell ferroptosis, improving blood clotting, and preventing osteoporosis. The increased global demand for VK2 has inspired interest in novel production strategies. In this review, various novel metabolic regulation strategies, including static and dynamic metabolic regulation, are summarized and discussed. Furthermore, the advantages and disadvantages of both strategies are analyzed in-depth to highlight the bottlenecks facing microbial VK2 production on an industrial scale. Finally, advanced metabolic engineering biotechnology for future microbial VK2 production will also be discussed. In summary, this review provides in-depth information and offers an outlook on metabolic engineering strategies for VK2 production.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biotecnología / Ingeniería Metabólica Idioma: En Revista: World J Microbiol Biotechnol Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biotecnología / Ingeniería Metabólica Idioma: En Revista: World J Microbiol Biotechnol Año: 2023 Tipo del documento: Article País de afiliación: China