Novel synthetic procedures for C2 substituted imidazoquinolines as ligands for the α/ß-interface of the GABAA-receptor.
Monatsh Chem
; 154(12): 1391-1404, 2023.
Article
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| MEDLINE
| ID: mdl-38020487
ABSTRACT
A series of substituted imidazoquinolines, a structurally related chemotype to pyrazoloquinolinones, a well-known class of GABAA ligands, was prepared via two synthetic procedures and the efficiency of these procedures were compared. One method relies on classical heterocyclic synthesis, the other one aims at late-stage decoration of a truncated scaffold via direct C-H functionalization. A pharmacological evaluation disclosed that one of the synthesized derivatives showed interesting activity on a α1ß3 containing receptor subtype. Supplementary Information The online version contains supplementary material available at 10.1007/s00706-022-02988-8.
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Banco de datos:
MEDLINE
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En
Revista:
Monatsh Chem
Año:
2023
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Article
País de afiliación:
Austria