In situ process analytical technology for real time viable cell density and cell viability during live-virus vaccine production.

Lomont, Justin P; Smith, Joseph P

Lomont, Justin P; Smith, Joseph P.

Afiliación

Lomont JP; Analytical Research & Development, MRL, Merck & Co., Inc., West Point, PA 19486, USA. Electronic address: justin.lomont@merck.com.
Smith JP; Process Research & Development, MRL, Merck & Co., Inc., West Point, PA 19486, USA. Electronic address: joseph.smith@merck.com.

Int J Pharm ; 649: 123630, 2024 Jan 05.

Article en En | MEDLINE | ID: mdl-38040394

Asunto(s)

Espectroscopía Dieléctrica; Vacunas; Cricetinae; Animales; Supervivencia Celular; Células CHO; Recuento de Células; Espectroscopía Dieléctrica/métodos; Tecnología

Palabras clave

Bioreactor; Capacitance; Cell culture; Dielectric spectroscopy; In situ analysis; LVV; Live virus vaccine; Multivariate data analysis; PAT; PLS; Partial least squares analysis; Process analytical technology; Vaccine development

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vacunas / Espectroscopía Dieléctrica Límite: Animals Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article

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