Food-Derived Peptides: Beneficial CNS Effects and Cross-BBB Transmission Strategies.
J Agric Food Chem
; 71(51): 20453-20478, 2023 Dec 27.
Article
en En
| MEDLINE
| ID: mdl-38085598
ABSTRACT
Food-derived peptides, as dietary supplements, have significant effects on promoting brain health and relieving central nervous system (CNS) diseases. However, the blood-brain barrier (BBB) greatly limits their in-brain bioavailability. Thus, overcoming the BBB to target the CNS is a major challenge for bioactive peptides in the prevention and treatment of CNS diseases. This review discusses improvement in the neuroprotective function of food-derived active peptides in CNS diseases, as well as the source of BBB penetrating peptides (BBB-shuttles) and the mechanism of transmembrane transport. Notably, this review also discusses various peptide modification methods to overcome the low permeability and stability of the BBB. Lipification, glycosylation, introduction of disulfide bonds, and cyclization are effective strategies for improving the penetration efficiency of peptides through the BBB. This review provides a new prospective for improving their neuroprotective function and developing treatments to delay or even prevent CNS diseases.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Barrera Hematoencefálica
/
Enfermedades del Sistema Nervioso Central
Límite:
Humans
Idioma:
En
Revista:
J Agric Food Chem
Año:
2023
Tipo del documento:
Article