Stat5a sobers up inTOXicated T cells.
Immunity
; 56(12): 2670-2672, 2023 Dec 12.
Article
en En
| MEDLINE
| ID: mdl-38091945
ABSTRACT
Exhausted T cells are largely hampered by epigenetically enforced mechanisms that limit their effector potential. In this issue of Immunity, Beltra et al. found that Stat5 can alter these epigenetic profiles when T cells transition from the Tpex precursor stage into differentiated cells. At this stage, enforced Stat5 expression increases the number of intermediate exhausted T cells and induces durable effector cells with superior anti-tumor activity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Immunity
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania