Advancing Meta-Selective C-H Amination through Non-Covalent Interactions.
J Am Chem Soc
; 146(3): 1735-1741, 2024 Jan 24.
Article
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| MEDLINE
| ID: mdl-38095630
ABSTRACT
Regioselective C-H amination of simple arenes is highly desirable, but accessing meta-sites of ubiquitous arenes has proven challenging due to the lack of both electronic and spatial preference. This study demonstrates the successful use of various privileged nitrogen-containing functionalities found in pharmaceutical compounds to direct meta-C-H amination of arenes, overcoming the long-standing requirement for a redundant directing group. The remarkable advancements in functional group accommodation for precise regiochemical control were achieved through the discovery of an unprecedented organo-initiator and the strategic utilization of non-covalent interactions. This protocol has been successfully applied in the concise synthesis and late-stage derivatization of drug molecules, which would have been otherwise challenging to achieve.
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MEDLINE
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En
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J Am Chem Soc
Año:
2024
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Article