The association between chronic sinonasal inflammation and nasopharyngeal carcinoma - A systematic review and meta-analysis.
Am J Otolaryngol
; 45(2): 104206, 2024.
Article
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| MEDLINE
| ID: mdl-38141564
ABSTRACT
PURPOSE:
There has been mounting evidence that inflammation is a key risk factor towards the development of certain cancers. Past studies have shown associations between nasopharyngeal carcinoma (NPC) and sinonasal tract inflammation. We aim to conduct a review and meta-analysis on the association between NPC and chronic sinus inflammation. MATERIALS ANDMETHODS:
We conducted a meta-analysis, searching 4 international databases from 1 January 1973 to 28 March 2022 for studies reporting on sinonasal inflammation and NPC in adult patients (>18 years old). We included cohort, case-control or cross-sectional studies. These studies must examine the association between a prior history of sinonasal inflammation and the risk of developing NPC. The outcome is the incidence of NPC in patients who had prior sinonasal inflammation.RESULTS:
8 studies (8245 NPC; 1,036,087 non-NPC) were included. The overall odds ratio (OR) of patients having NPC after reporting sinonasal inflammation was 1.81 (95 % CI 1.73-1.89). Of note, chronic rhinosinusitis (CRS) (OR of 1.78 (95 %-CI 1.68-1.90)) was more closely associated with an increased risk of NPC, as compared to allergic rhinitis (AR) (OR of 1.60 (95 %-CI 1.52-1.68)).CONCLUSION:
Chronic sinonasal inflammation is significantly associated with NPC in this systemic review and meta-analysis. The true cause-effect relationship and the potential effects of targeted screening need to be explored thoroughly with large scale prospective studies.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Nasofaríngeas
/
Carcinoma Nasofaríngeo
Tipo de estudio:
Systematic_reviews
Límite:
Humans
/
Male
Idioma:
En
Revista:
Am J Otolaryngol
Año:
2024
Tipo del documento:
Article