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Exploring Paxlovid Efficacy in COVID-19 Patients with MAFLD: Insights from a Single-Center Prospective Cohort Study.
Buchynskyi, Mykhailo; Oksenych, Valentyn; Kamyshna, Iryna; Kamyshnyi, Oleksandr.
Afiliación
  • Buchynskyi M; Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.
  • Oksenych V; Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, 5020 Bergen, Norway.
  • Kamyshna I; Department of Medical Rehabilitation, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.
  • Kamyshnyi O; Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.
Viruses ; 16(1)2024 01 12.
Article en En | MEDLINE | ID: mdl-38257811
ABSTRACT
This study investigates the intricate interplay between Metabolic-associated Fatty Liver Disease (MAFLD) and COVID-19, exploring the impact of MAFLD on disease severity, outcomes, and the efficacy of the antiviral agent Paxlovid (nirmatrelvir/ritonavir). MAFLD, affecting a quarter of the global population, emerges as a potential risk factor for severe COVID-19, yet the underlying pathophysiological mechanisms remain elusive. This study focuses on the clinical significance of Paxlovid, the first orally bioavailable antiviral agent granted Emergency Use Authorization in the United States. Notably, outcomes from phase II/III trials exhibit an 88% relative risk reduction in COVID-19-associated hospitalization or mortality among high-risk patients. Despite conflicting data on the association between MAFLD and COVID-19 severity, this research strives to bridge the gap by evaluating the effectiveness of Paxlovid in MAFLD patients with COVID-19, addressing the scarcity of relevant studies.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Prolina / Ritonavir / Enfermedad del Hígado Graso no Alcohólico / COVID-19 / Lactamas / Leucina / Nitrilos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Viruses Año: 2024 Tipo del documento: Article País de afiliación: Ucrania

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Prolina / Ritonavir / Enfermedad del Hígado Graso no Alcohólico / COVID-19 / Lactamas / Leucina / Nitrilos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Viruses Año: 2024 Tipo del documento: Article País de afiliación: Ucrania