Precision Medicine in Parkinson's Disease Using Induced Pluripotent Stem Cells.
Adv Healthc Mater
; 13(21): e2303041, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38269602
ABSTRACT
Parkinson's disease (PD) is one of the most devastating neurological diseases; however, there is no effective cure yet. The availability of human induced pluripotent stem cells (iPSCs) provides unprecedented opportunities to understand the pathogenic mechanism and identification of new therapy for PD. Here a new model system of PD, including 2D human iPSC-derived midbrain dopaminergic (mDA) neurons, 3D iPSC-derived midbrain organoids (MOs) with cellular complexity, and more advanced microphysiological systems (MPS) with 3D organoids, is introduced. It is believed that successful integrations and applications of iPSC, organoid, and MPS technologies can bring new insight on PD's pathogenesis that will lead to more effective treatments for this debilitating disease.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Organoides
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Células Madre Pluripotentes Inducidas
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Medicina de Precisión
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Neuronas Dopaminérgicas
Límite:
Animals
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Humans
Idioma:
En
Revista:
Adv Healthc Mater
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos