A novel predictive marker for placental abruption with composite adverse outcomes: creatinine-fibrinogen ratio.
Arch Gynecol Obstet
; 310(1): 353-358, 2024 07.
Article
en En
| MEDLINE
| ID: mdl-38270622
ABSTRACT
PURPOSE:
To develop a new cost-effective marker named creatinine-fibrinogen ratio (CFR) for the prediction of composite adverse outcomes (CAO) in placental abruption cases.METHODS:
A total of 109 placental abruption patients (30 with adverse outcomes, 79 without adverse outcomes) were enrolled in this retrospective cohort study. Patients with at least one of the features listed below were included in the abruption with CAO group requirement of blood product transfusion (erythrocyte suspension, fresh frozen plasma, pooled thrombocyte, thrombocyte apheresis), development of acute kidney injury or disseminated intravascular coagulation, and need for intensive care unit. Laboratory parameters and CFR values at admission to the hospital were compared between the two groups.RESULTS:
Higher creatinine and lower fibrinogen levels were found in the CAO group (p = 0.007 and p < 0.001 respectively). The CFR value of the CAO group was significantly higher (p < 0.001). In the ROC curve analysis performed to investigate the value of CFR in CAO prediction, the area under the curve (AUC) was calculated as 0,802 (95% CI 0.709-0.895, 77% sensitivity, 65% specificity).CONCLUSION:
CFR seems to be a practical marker for the prediction of CAOs in pregnant women with ablatio placenta.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fibrinógeno
/
Biomarcadores
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Creatinina
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Desprendimiento Prematuro de la Placenta
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Arch Gynecol Obstet
Asunto de la revista:
GINECOLOGIA
/
OBSTETRICIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Turquía