One-pot chemoenzymatic syntheses of non-canonical amino acids.
J Ind Microbiol Biotechnol
; 512024 Jan 09.
Article
en En
| MEDLINE
| ID: mdl-38271597
ABSTRACT
Despite their prevalent use in drug discovery and protein biochemistry, non-canonical amino acids are still challenging to synthesize through purely chemical means. In recent years, biocatalysis has emerged as a transformative paradigm for small-molecule synthesis. One strategy to further empower biocatalysis is to use it in combination with modern chemical reactions and take advantage of the strengths of each method to enable access to challenging structural motifs that were previously unattainable using each method alone. In this Mini-Review, we highlight several recent case studies that feature the synergistic use of chemical and enzymatic transformations in one pot to synthesize novel non-canonical amino acids. ONE-SENTENCE SUMMARY:
This Mini-Review highlights several recent case studies that feature the synergistic use of chemical and enzymatic transformations in one pot to synthesize novel non-canonical amino acids.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aminas
/
Aminoácidos
Idioma:
En
Revista:
J Ind Microbiol Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
/
MICROBIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos