Atypical Spindle Cell/Pleomorphic Lipomatous Tumor.
Surg Pathol Clin
; 17(1): 97-104, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38278611
ABSTRACT
Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare soft tissue neoplasm, commonly arising in the subcutis (more common than deep soft tissue) of limbs and limb girdles during mid-adulthood. ASCPLT is histologically a lipogenic neoplasm with ill-defined margins composed of a variable amount of spindle to pleomorphic/multinucleated cells within a fibromyxoid stroma. ASCPLTs lack MDM2 amplification, but a large subset show RB1 deletion and variable expression of CD34. Though initially thought to be the malignant form of spindle cell lipoma, ASCPLTs are benign with local recurrences (â¼10-15%) and no well-documented dedifferentiation or metastasis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de los Tejidos Blandos
/
Lipoma
/
Liposarcoma
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Surg Pathol Clin
Año:
2024
Tipo del documento:
Article