Is milbemycin a game changer against antifungal drug-resistant mycoses?
Med Mycol
; 62(2)2024 Jan 27.
Article
en En
| MEDLINE
| ID: mdl-38285608
ABSTRACT
Milbemycin oximes are macrocyclic lactones that have a broad spectrum of activity against nematode infection in animals. They are known to block drug efflux, which increases the susceptibility of fungi to azoles. We investigated the effects of milbemycin on the azole susceptibility of fungi (Aspergillus fumigatus, Candida albicans, C. auris, Cryptococcus neoformans, and Trichophyton rubrum). To screen for changes in azole susceptibility, fungal growth was tested on a culture medium containing 1 µg/ml milbemycin. The results showed that milbemycin increased the azole susceptibility of azole-resistant strains of C. albicans, C. auris, C. neoformans, and T. rubrum. Thus, milbemycin might be useful against antifungal drug-resistant strains.
Milbemycin blocks drug efflux and increases the azole susceptibility of azole-resistant strains of Candida albicans, C. auris, Cryptococcus neoformans, and Trichophyton rubrum. This drug is expected to be a game changer against antifungal drug-resistant infections.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Macrólidos
/
Cryptococcus neoformans
/
Micosis
Límite:
Animals
Idioma:
En
Revista:
Med Mycol
/
Med. mycol
/
Medical mycology
Asunto de la revista:
MEDICINA VETERINARIA
/
MICROBIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón