Structurally Diverse Macrolactams from an Antarctic Streptomyces Species.
J Nat Prod
; 87(2): 404-414, 2024 02 23.
Article
en En
| MEDLINE
| ID: mdl-38288586
ABSTRACT
Twelve new polyenic macrolactams, cyclamenols G-R (1 and 3-13), together with the known analogue cyclamenol A (2), were isolated from Streptomyces sp. OUCMDZ-4348. Their structures were elucidated by spectroscopic analysis, quantum chemical calculations, chemical derivatizations, and Mosher's methods. The sequenced genome of OUCMDZ-4348 revealed the putative biosynthetic gene cluster of cyclamenols. It was proposed that the polycyclic natural products, cyclamenols H-R, might be formed from cyclamenols A and G through nonenzymatic intramolecular cycloadditions and oxidative cyclizations.
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MEDLINE
Asunto principal:
Streptomyces
Idioma:
En
Revista:
J Nat Prod
Año:
2024
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Article