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Near-Infrared Fluorescent Silica Nanoparticles Based on Gold-Silver Alloy Nanoclusters for Clinical Diagnosis.
Ichimaru, Hiroaki; Kikuchi, Shigetoshi.
Afiliación
  • Ichimaru H; Tsukuba Research Laboratories, Tokuyama Corporation.
  • Kikuchi S; Tsukuba Research Laboratories, Tokuyama Corporation.
Chem Pharm Bull (Tokyo) ; 72(1): 121-126, 2024.
Article en En | MEDLINE | ID: mdl-38296514
ABSTRACT
In clinical diagnosis, fluorescent particles are applied to detect analytes in biofluids, such as blood and saliva. However, current fluorescence detection methods have not been optimized to account for the overlapping autofluorescence peaks of biological substances. Gold and silver nanoclusters are known to the novel fluorescent materials and their emission wavelengths depend on cluster size. In this study, we developed fluorescent silica nanoparticles using gold-silver alloy nanoclusters and chitosan (CS) (NH2-SiO2@Au@CS@AuAg) by the layer-by-layer method. Under UV-light irradiation at 365 nm, the emission wavelength of NH2-SiO2@Au@CS@AuAg reached 750 nm in the near-IR region. Scanning electron microscopy images revealed that the shape of NH2-SiO2@Au@CS@AuAg was uniform and spherical. The fluorescence spectrum of horse blood obtained in the presence of NH2-SiO2@Au@CS@AuAg contained a specific fluorescence peak attributed to NH2-SiO2@Au@CS@AuAg, which was distinguishable from the autofluorescence peaks. These results showed that NH2-SiO2@Au@CS@AuAg has advantageous fluorescence properties for clinical diagnostic applications.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Nanopartículas del Metal / Aleaciones de Oro Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Chem Pharm Bull (Tokyo) Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Nanopartículas del Metal / Aleaciones de Oro Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Chem Pharm Bull (Tokyo) Año: 2024 Tipo del documento: Article