Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.
Nat Cell Biol
; 26(2): 250-262, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38321203
ABSTRACT
A key aspect of nutrient absorption is the exquisite division of labour across the length of the small intestine, with individual nutrients taken up at different proximaldistal positions. For millennia, the small intestine was thought to comprise three segments with indefinite borders the duodenum, jejunum and ileum. By examining the fine-scale longitudinal transcriptional patterns that span the mouse and human small intestine, we instead identified five domains of nutrient absorption that mount distinct responses to dietary changes, and three regional stem cell populations. Molecular domain identity can be detected with machine learning, which provides a systematic method to computationally identify intestinal domains in mice. We generated a predictive model of transcriptional control of domain identity and validated the roles of Ppar-δ and Cdx1 in patterning lipid metabolism-associated genes. These findings represent a foundational framework for the zonation of absorption across the mammalian small intestine.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Duodeno
/
Intestino Delgado
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Cell Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos