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Na2S2O3 Catalyzed Three-Component Synthesis and Anti-Bacterial Activity of 3-Methyl-4-(hetero)arylmethylene isoxazole-5(4H)-ones.
Bi, Yongchang; Wang, Jingjun; Bian, Xingyu; Chen, Mingyue; Zhu, Guangyuan; Zhang, Yumin; Gu, Qiang.
Afiliación
  • Bi Y; Department of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
  • Wang J; Department of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
  • Bian X; Department of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
  • Chen M; Department of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
  • Zhu G; Department of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
  • Zhang Y; Department of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
  • Gu Q; Department of Chemical Engineering and Applied Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
Chem Biodivers ; 21(4): e202400073, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38366673
ABSTRACT
An efficient and green method for synthesizing 3-methyl-4-(hetero) arylmethylene isoxazole-5(4H)-ones was developed using a recyclable and environmental-friendly catalyst, Na2S2O3, and 16 target compounds were successfully synthesized under the obtained optimal reaction condition. Using rifampicin as a positive control, the antibacterial activity of all synthesized compounds was tested by micro dilution method, among them, 3-methyl-4-[(2,4-dimethoxyphenyl) methylene]-isoxazole-5-one (4 m) presented wonderful antimicrobial activity, which may contribute to the development of anti-tuberculosis drugs.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bacterias / Antibacterianos Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bacterias / Antibacterianos Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article