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CRISPR/Cas9: an overview of recent developments and applications in cancer research.
Devi, Shamjetsabam Nandibala; Rana, Rashmi; Malik, Priyanka; Ganguly, Nirmal Kumar.
Afiliación
  • Devi SN; Department of Biotechnology and Research, Sir Ganga Ram Hospital New Delhi-110060, India.
  • Rana R; Department of Biotechnology and Research, Sir Ganga Ram Hospital New Delhi-110060, India.
  • Malik P; Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU), Rampura Phul, Bathinda-151103, Punjab, India.
  • Ganguly NK; Department of Biotechnology and Research, Sir Ganga Ram Hospital New Delhi-110060, India.
Int J Surg ; 2024 Feb 21.
Article en En | MEDLINE | ID: mdl-38377059
ABSTRACT
CRISPR-Cas9 has risen as a potent gene editing method with vast potential across numerous domains, including its application in cancer research and therapy. This review article provides an extensive overview of the research that has been done so far on CRISPR-Cas9 with an emphasis on how it could be utilized in the treatment of cancer. We go into the underlying ideas behind CRISPR-Cas9, its mechanisms of action, and its application for the study of cancer biology. Furthermore, we investigate the various uses of CRISPR-Cas9 in cancer research, spanning from the discovery of genes and the disease to the creation of novel therapeutic approaches. We additionally discuss the challenges and limitations posed by CRISPR-Cas9 technology and offer insights into the potential applications and future directions of this cutting-edge field of research. The article intends to consolidate the present understanding and stimulate more research into CRISPR-Cas9's promise as a game-changing tool for cancer research and therapy.

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Int J Surg Año: 2024 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Int J Surg Año: 2024 Tipo del documento: Article País de afiliación: India