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Modeling Acute Myeloid Leukemia Using StarPEG-Heparin Hydrogels.
Holloway, P Lewen; Ravichandran, Akhilandeshwari; Clegg, Julien; Bruedigam, Claudia; Bray, Laura J.
Afiliación
  • Holloway PL; School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Kelvin Grove, QLD, Australia.
  • Ravichandran A; School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Kelvin Grove, QLD, Australia.
  • Clegg J; School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Kelvin Grove, QLD, Australia.
  • Bruedigam C; ARC Training Centre for Cell and Tissue Engineering Technologies, Queensland University of Technology, Kelvin Grove, QLD, Australia.
  • Bray LJ; Cancer Program, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Herston, QLD, Australia.
Methods Mol Biol ; 2764: 61-73, 2024.
Article en En | MEDLINE | ID: mdl-38393589
ABSTRACT
Biomimetic semi-synthetic hydrogels formed from a combination of star-shaped poly(ethylene glycol) (starPEG) and the glycosaminoglycan, heparin, allows for the three-dimensional (3D) culture of various cells and tissues. In this chapter, we describe methods for the use of starPEG-heparin hydrogels to cultivate primary and immortalized human acute myeloid leukemia (AML) cells. The resulting 3D culture models allow for the study of AML development and response to chemotherapeutic agents.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Heparina / Leucemia Mieloide Aguda Límite: Humans Idioma: En Revista: Methods Mol Biol / Methods in molecular biology / Methods mol. biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Heparina / Leucemia Mieloide Aguda Límite: Humans Idioma: En Revista: Methods Mol Biol / Methods in molecular biology / Methods mol. biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Australia