Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia.

Günther, Gunar; Mhuulu, Lusia; Diergaardt, Azaria; Dreyer, Viola; Moses, Maria; Anyolo, Kaarna; Ruswa, Nunurai; Claassens, Mareli; Niemann, Stefan; Nepolo, Emmanuel

Günther, Gunar; Mhuulu, Lusia; Diergaardt, Azaria; Dreyer, Viola; Moses, Maria; Anyolo, Kaarna; Ruswa, Nunurai; Claassens, Mareli; Niemann, Stefan; Nepolo, Emmanuel.

Emerg Infect Dis ; 30(3): 568-571, 2024 Mar.

Article en En | MEDLINE | ID: mdl-38407158

ABSTRACT

ABSTRACT

Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in a teenager in Namibia, despite an optimal background regimen and adherence. The report highlights the risk for bedaquiline resistance development and the need for rapid drug-resistance testing.

Asunto(s)

Tuberculosis Resistente a Múltiples Medicamentos; Adolescente; Humanos; Namibia/epidemiología; Tuberculosis Resistente a Múltiples Medicamentos/tratamiento farmacológico; Tuberculosis Resistente a Múltiples Medicamentos/epidemiología; Resultado del Tratamiento; Diarilquinolinas/farmacología; Diarilquinolinas/uso terapéutico

Palabras clave

MDR TB; Namibia; TB; antimicrobial resistance; bacteria; bedaquiline; respiratory infections; tuberculosis; tuberculosis and other mycobacteria

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tuberculosis Resistente a Múltiples Medicamentos Límite: Adolescent / Humans País/Región como asunto: Africa Idioma: En Revista: Emerg Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article

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