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Yellow leaf green tea modulates the AMPK/ACC/SREBP1c signaling pathway and gut microbiota in high-fat diet-induced mice to alleviate obesity.
Tian, Baoming; Pan, Yizhu; Zhou, Xue; Jiang, Yuezhi; Zhang, Xiangchun; Luo, Xudong; Yang, Kai.
Afiliación
  • Tian B; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China.
  • Pan Y; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China.
  • Zhou X; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China.
  • Jiang Y; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China.
  • Zhang X; Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, China.
  • Luo X; Sichuan Three MT. TEA-INDUSTRY Co., Ltd, Guangyuan, China.
  • Yang K; College of Food Science and Technology, Zhejiang University of Technology, Huzhou, China.
J Sci Food Agric ; 104(10): 5882-5895, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-38407390
ABSTRACT

BACKGROUND:

Yellow leaf green tea (YLGT) is a new variety of Camellia sinensis (L.) O. Ktze, which has yellow leaves and the unique qualities of 'three green through three yellow'. The present study aimed to investigate the anti-obesity effect of YLGT in mice fed a high-fat diet (HFD) and to explore the potential mechanisms by regulating the AMPK/ACC/SREBP1c signaling pathways and gut microbiota.

RESULTS:

The results showed that YLGT aqueous extract reduced body weight, hepatic inflammation, fat accumulation and hyperlipidemia in HFD-induced C57BL/6J mice, and also accelerated energy metabolism, reduced fat synthesis and suppressed obesity by activating the AMPK/CPT-1α signaling pathway and inhibiting the FAS/ACC/SREBP-1c signaling pathway. Fecal microbiota transplantation experiment further confirmed that the alteration of gut microbiota (e.g. increasing unclassified_Muribaculaceae and decreasing Colidextribacter) might be an important cause of YLGT water extract inhibiting obesity.

CONCLUSION:

In conclusion, YLGT has a broad application prospect in the treatment of obesity and the development of anti-obesity function beverages. © 2024 Society of Chemical Industry.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Extractos Vegetales / Transducción de Señal / Hojas de la Planta / Camellia sinensis / Microbioma Gastrointestinal / Obesidad Límite: Animals / Humans / Male Idioma: En Revista: J Sci Food Agric Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Extractos Vegetales / Transducción de Señal / Hojas de la Planta / Camellia sinensis / Microbioma Gastrointestinal / Obesidad Límite: Animals / Humans / Male Idioma: En Revista: J Sci Food Agric Año: 2024 Tipo del documento: Article País de afiliación: China