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Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas.
Aoki, Hironori; Takasawa, Akira; Yamamoto, Eiichiro; Niinuma, Takeshi; Yamano, Hiro-O; Harada, Taku; Kubo, Toshiyuki; Yorozu, Akira; Kitajima, Hiroshi; Ishiguro, Kazuya; Kai, Masahiro; Katanuma, Akio; Shinohara, Toshiya; Nakase, Hiroshi; Sugai, Tamotsu; Osanai, Makoto; Suzuki, Hiromu.
Afiliación
  • Aoki H; Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-Ku, Sapporo, 060-8556, Japan.
  • Takasawa A; Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan.
  • Yamamoto E; Department of Gastroenterology and Endoscopy, Koyukai Shin-Sapporo Hospital, Sapporo, Japan.
  • Niinuma T; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Yamano HO; Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-Ku, Sapporo, 060-8556, Japan.
  • Harada T; Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-Ku, Sapporo, 060-8556, Japan.
  • Kubo T; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Yorozu A; Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-Ku, Sapporo, 060-8556, Japan.
  • Kitajima H; Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan.
  • Ishiguro K; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Kai M; Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-Ku, Sapporo, 060-8556, Japan.
  • Katanuma A; Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-Ku, Sapporo, 060-8556, Japan.
  • Shinohara T; Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-Ku, Sapporo, 060-8556, Japan.
  • Nakase H; Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-Ku, Sapporo, 060-8556, Japan.
  • Sugai T; Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan.
  • Osanai M; Department of Pathology, Teine-Keijinkai Hospital, Sapporo, Japan.
  • Suzuki H; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
BMC Gastroenterol ; 24(1): 91, 2024 Mar 01.
Article en En | MEDLINE | ID: mdl-38429655
ABSTRACT

BACKGROUND:

Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rarely methylated in sessile serrated lesions (SSLs). In the present study, we aimed to further characterize the expression of SMOC1 in early colorectal lesions.

METHODS:

SMOC1 expression was analyzed immunohistochemically in a series of colorectal tumors (n = 199) and adjacent normal colonic tissues (n = 112).

RESULTS:

SMOC1 was abundantly expressed in normal colon and SSLs while it was significantly downregulated in TSAs, advanced adenomas and cancers. Mean immunohistochemistry scores were as follows normal colon, 24.2; hyperplastic polyp (HP), 18.9; SSL, 23.8; SSL with dysplasia (SSLD)/SSL with early invasive cancer (EIC), 15.8; TSA, 5.4; TSA with high grade dysplasia (HGD)/EIC, 4.7; non-advanced adenoma, 21.4; advanced adenoma, 11.9; EIC, 10.9. Higher levels SMOC1 expression correlated positively with proximal colon locations and flat tumoral morphology, reflecting its abundant expression in SSLs. Among TSAs that contained both flat and protruding components, levels of SMOC1 expression were significantly lower in the protruding components.

CONCLUSION:

Our results suggest that reduced expression of SMOC1 is associated with progression of TSAs and conventional adenomas and that SMOC1 expression may be a biomarker for diagnosis of serrated lesions and risk prediction in colorectal tumors.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenoma / Pólipos del Colon Límite: Humans Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Adenoma / Pólipos del Colon Límite: Humans Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón