High level 27-HC impairs trophoblast cell invasion and migration via LXR in pre-eclampsia.
Exp Cell Res
; 437(1): 113979, 2024 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-38462209
ABSTRACT
INTRODUCTION:
To explore the potential impact of 27-hydroxycholesterol (27-HC) on trophoblast cell function in pre-eclampsia.RESULTS:
The levels of 27-HC and the expression of CYP27A1 are upregulated in clinical samples of PE. Furthermore, high concentrations of 27-HC can inhibit the invasion and migration ability of trophoblast cells in vitro, and this inhibitory effect is weakened after LXR silencing. In HTR8/SVneo cells treated with 27-HC, the expression of ABCA1/ABCG1 are increased. Finally, we established a mouse model of PE using l-NAME (N-Nitro-l-Arginine Methyl Ester). We found an increase in the levels of 27-HC in the peripheral blood serum of the PE mouse model, and an upregulation of CYP27A1 and LXR expressions in the placenta of the PE mouse model.CONCLUSION:
27-HC inhibits the invasion and migration ability of trophoblast cells by activating the LXR signaling pathway, which is involved in the pathogenesis of Pre-eclampsia(PE).Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Preeclampsia
Límite:
Animals
/
Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Exp Cell Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
China