Your browser doesn't support javascript.
loading
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue.
Lennartz, Maximilian; Amezada, Daniela; Höflmayer, Doris; Dwertmann Rico, Sebastian; von Bargen, Clara; Kind, Simon; Reiswich, Viktor; Viehweger, Florian; Lutz, Florian; Bertram, Veit; Fraune, Christoph; Gorbokon, Natalia; Weidemann, Sören; Hube-Magg, Claudia; Menz, Anne; Uhlig, Ria; Krech, Till; Hinsch, Andrea; Burandt, Eike; Sauter, Guido; Simon, Ronald; Kluth, Martina; Marx, Andreas H; Lebok, Patrick; Dum, David; Minner, Sarah; Jacobsen, Frank; Clauditz, Till S; Bernreuther, Christian; Steurer, Stefan.
Afiliación
  • Lennartz M; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Amezada D; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Höflmayer D; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Dwertmann Rico S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • von Bargen C; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Kind S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Reiswich V; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Viehweger F; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Lutz F; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Bertram V; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Fraune C; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Gorbokon N; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Weidemann S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Hube-Magg C; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Menz A; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Uhlig R; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Krech T; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Hinsch A; the Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany (Krech, Lebok).
  • Burandt E; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Sauter G; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Simon R; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Kluth M; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Marx AH; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Lebok P; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Dum D; the Department of Pathology, Academic Hospital Fuerth, Fuerth, Germany (Marx).
  • Minner S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Jacobsen F; the Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany (Krech, Lebok).
  • Clauditz TS; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Bernreuther C; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
  • Steurer S; From the Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Lennartz, Amezada, Höflmayer, Dwertmann Rico, von Bargen, Kind, Reiswich, Viehweger, Lutz, Bertram, Fraune, Gorbokon, Weidemann, Hube-Magg, Menz, Uhlig, Krech, Hinsch, Burandt, Sauter, Simon, Kluth, Lebok
Arch Pathol Lab Med ; 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38484775
ABSTRACT
CONTEXT.­ Steroidogenic acute regulatory (StAR) protein is a mitochondrial transport protein with a critical regulatory role for steroid hormone production. The tissue distribution of StAR expression is limited to few human normal tissues. OBJECTIVE.­ To assess the diagnostic and prognostic value of StAR immunohistochemistry analysis. DESIGN.­ A tissue microarray containing 19 202 samples from 152 different tumor types and subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. RESULT.­ StAR immunostaining occurred in 198 (1.2%) of the 17 135 analyzable tumors. StAR expression was observed in 27 of 152 tumor categories, 9 of which included at least 1 strongly positive case. The highest rate of StAR positivity occurred in Leydig cell tumors of the testis and the ovary (100%), steroid cell tumors of the ovary (100%), adrenocortical carcinomas (93%) and adenomas (87%), Sertoli-Leydig cell tumors (67%) and granulosa cell tumors of the ovary (56%), as well as seminomas (7%). Nineteen other tumor entities showed-a usually weak-StAR positivity in less than 6% of cases. A comparison with preexisting Melan-A (a melanocyte antigen) data revealed that StAR was more often positive in adrenocortical neoplasms and in Leydig cell tumors while StAR (but not Melan-A) was negative in Sertoli cell tumors. CONCLUSIONS.­ Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Arch Pathol Lab Med Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Arch Pathol Lab Med Año: 2024 Tipo del documento: Article