In platelet single donor apheresis, platelet factor 4 levels correlated with donor's age and decreased during storage.
Sci Rep
; 14(1): 6231, 2024 03 14.
Article
en En
| MEDLINE
| ID: mdl-38485973
ABSTRACT
The human population is ageing worldwide. The World Health Organization estimated that the world's population of people aged 60 years and older will increase to at least 30%, coinciding with a growing frequency of cognitive and cardiovascular disease. Recently, in preclinical studies platelet Factor 4 (PF4) was presented as a pro-cognitive factor. This molecule is released by platelets in the circulation and could be present in blood products destined for transfusion. We wondered if PF4 levels are correlated to the age of the blood donor or to the storage time of platelet concentrates (PCs) intended for transfusion? We observed higher levels of PF4 in PCs from elderly donors compared to younger donors, while PC storage time did not determine PF4 levels expression.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factor Plaquetario 4
/
Plaquetoferesis
Límite:
Aged
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Humans
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Middle aged
Idioma:
En
Revista:
Sci Rep
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia