Effect of Liver Segments and Hepatic Fibrosis Grade on Repeatability, Reliability, and Diagnostic Efficiency of Intravoxel Incoherent Motion
Curr Med Imaging
; 20: e15734056288517, 2024.
Article
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| MEDLINE
| ID: mdl-38494942
ABSTRACT
BACKGROUND:
Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) is considered a potential marker of hepatic fibrosis (HF).OBJECTIVE:
To explore the influencing factors of repeatability and reliability in IVIM-DWI parameters of ROI-based liver segments in participants with HF and healthy volunteers (HV) and to assess the diagnostic efficiency of these parameters in HF.METHODS:
Participants with early HF (EHF, n=59) or advanced HF (AHF, n=38) and HV (n=48) were recruited. Two examiners measured IVIM data using mono-, bi-exponential and stretched exponential models. The results and influencing factors of repeatability and reliability of IVIM-DWI, and the diagnostic efficiency were analyzed.RESULTS:
The repeatability of D* (CV 26.62-41.47%) and DDC (CV 18.01-34.40%) was poor, the repeatability of ADC (CV 4.95-9.76%), D (CV 7.09-15.52%), f (CV 9.35-17.15%), and α (CV 7.48-13.81%) was better; ordered logistic regression showed statistically significant results of IVIM-derived parameters; the reliability showed no obvious trend, and ordered logistic regression showed statistically significant results of IVIMderived parameters, groups, and partial hepatic segments (all p<0.001). IVIM-derived parameters with relatively good repeatability (CV<20%) and reliability (ICC>0.4) were used to establish regression models for differential diagnosis. The AUC of regression models was 0.744-0.783 (EHF vs. AHF), but no statistically significant parameters were found in the HV vs EHF comparison.CONCLUSION:
IVIM-derived parameters were the most important factors affecting the repeatability and reliability, while staging of HF and hepatic segments may be the influencing factors of reliability. IVIM-derived parameters showed medium diagnostic efficiency in distinguishing between EHF and AHF.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Imagen de Difusión por Resonancia Magnética
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Hígado
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Cirrosis Hepática
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Curr Med Imaging
Año:
2024
Tipo del documento:
Article
País de afiliación:
China