Association of serum galectin-3 levels with mortality and cardiovascular disease outcomes in hemodialysis patients: a systematic review and dose-response meta-analysis.
Int Urol Nephrol
; 56(8): 2755-2767, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38519721
ABSTRACT
BACKGROUND:
Galectin-3 has been proposed as a candidate marker for cardiovascular risk stratification, although its role in kidney failure is unclear. The aim of this systematic review was to assess the association of serum galectin-3 levels with overall survival and cardiovascular outcomes among hemodialysis patients.METHODS:
Medline, Scopus, Web of Science and CENTRAL were systematically searched from inception till Aug 20, 2023. Observational studies evaluating the association of serum galectin-3 with mortality, cardiovascular disease and arterial stiffness in hemodialysis patients were included. The exposure-response relationship between galectin-3 and mortality was explored by dose-response meta-analysis using restricted cubic splines in a one-stage approach.RESULTS:
Overall, 13 studies were included (9 cohort and 4 cross-sectional), comprising 6025 hemodialysis individuals. Increasing galectin-3 values were associated with greater all-cause mortality risk (χ2 18.71, p-value < 0.001) and an insignificant trend toward higher cardiovascular mortality risk (χ2 5.06, p-value 0.079). Compared to a reference galectin-3 value of 10 ng/ml, all-cause mortality risk was significantly higher with levels of 20 ng/ml (Hazard ratio-HR 2.62, 95% confidence intervals-CI 1.66-4.15), 30 ng/ml (HR 3.78, 95% CI 2.05-6.97) and 40 ng/ml (HR 4.01, 95% CI 2.14-7.52). Qualitative synthesis of evidence indicated that serum galectin-3 may be linked to abdominal aortic calcification severity and progression, as well as to left ventricular systolic and diastolic dysfunction.CONCLUSIONS:
This study suggests that high serum galectin-3 levels are associated with greater all-cause mortality risk among patients on maintenance hemodialysis. Preliminary cross-sectional evidence indicates that serum galectin-3 may be associated with arterial stiffness and left ventricular dysfunction.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
Diálisis Renal
/
Galectina 3
Límite:
Humans
Idioma:
En
Revista:
Int Urol Nephrol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Grecia