Target trial emulation for comparative effectiveness research with observational data: Promise and challenges for studying medications for opioid use disorder.
Addiction
; 119(7): 1313-1321, 2024 07.
Article
en En
| MEDLINE
| ID: mdl-38519819
ABSTRACT
Medications for opioid use disorder (MOUD) increase retention in care and decrease mortality during active treatment; however, information about the comparative effectiveness of different forms of MOUD is sparse. Observational comparative effectiveness studies are subject to many types of bias; a robust framework to minimize bias would improve the quality of comparative effectiveness evidence. This paper discusses the use of target trial emulation as a framework to conduct comparative effectiveness studies of MOUD with administrative data. Using examples from our planned research project comparing buprenorphine-naloxone and extended-release naltrexone with respect to the rates of MOUD discontinuation, we provide a primer on the challenges and approaches to employing target trial emulation in the study of MOUD.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Investigación sobre la Eficacia Comparativa
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Tratamiento de Sustitución de Opiáceos
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Combinación Buprenorfina y Naloxona
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Naltrexona
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Antagonistas de Narcóticos
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Trastornos Relacionados con Opioides
Límite:
Humans
Idioma:
En
Revista:
Addiction
Asunto de la revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos