Your browser doesn't support javascript.
loading
A numerical study on the siphonic effect of enhanced external counterpulsation at lower extremities with a coupled 0D-1D closed-loop personalized hemodynamics model.
Zhang, Qi; Zhang, Ya-Hui; Hao, Li-Ling; Xu, Xuan-Hao; Wu, Gui-Fu; Lin, Ling; Xu, Xiu-Li; Qi, Lin; Tian, Shuai.
Afiliación
  • Zhang Q; College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning 110167, China.
  • Zhang YH; Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518033, China.
  • Hao LL; College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning 110167, China. Electronic address: haoll@bmie.neu.edu.cn.
  • Xu XH; Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518033, China.
  • Wu GF; Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518033, China.
  • Lin L; Department of Radiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518033, China.
  • Xu XL; Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518033, China. Electronic address: missyoudream@163.com.
  • Qi L; College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, Liaoning 110167, China. Electronic address: qilin@bmie.neu.edu.cn.
  • Tian S; Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518033, China. Electronic address: tiansh9@mail.sysu.edu.cn.
J Biomech ; 166: 112057, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38520934
ABSTRACT
Enhanced external counterpulsation (EECP) is a treatment and rehabilitation approach for ischemic diseases, including coronary artery disease. Its therapeutic benefits are primarily attributed to the improved blood circulation achieved through sequential mechanical compression of the lower extremities. However, despite the crucial role that hemodynamic effects in the lower extremity arteries play in determining the effectiveness of EECP treatment, most studies have focused on the diastole phase and ignored the systolic phase. In the present study, a novel siphon model (SM) was developed to investigate the interdependence of several hemodynamic parameters, including pulse wave velocity, femoral flow rate, the operation pressure of cuffs, and the mean blood flow changes in the femoral artery throughout EECP therapy. To verify the accuracy of the SM, we coupled the predicted afterload in the lower extremity arteries during deflation using SM with the 0D-1D patient-specific model. Finally, the simulation results were compared with clinical measurements obtained during EECP therapy to verify the applicability and accuracy of the SM, as well as the coupling method. The precision and reliability of the previously developed personalized approach were further affirmed in this study. The average waveform similarity coefficient between the simulation results and the clinical measurements during the rest state exceeded 90%. This work has the potential to enhance our understanding of the hemodynamic mechanisms involved in EECP treatment and provide valuable insights for clinical decision-making.
Asunto(s)
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Contrapulsación / Análisis de la Onda del Pulso Límite: Humans Idioma: En Revista: J Biomech / J. biomech / Journal of biomechanics Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Contrapulsación / Análisis de la Onda del Pulso Límite: Humans Idioma: En Revista: J Biomech / J. biomech / Journal of biomechanics Año: 2024 Tipo del documento: Article País de afiliación: China