Direct comparison of the diagnostic performance of growth differentiation factor 8 in pediatric versus adult heart failure.
Clin Chim Acta
; 557: 117883, 2024 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-38521162
ABSTRACT
INTRODUCTION:
Growth differentiation factor 8 (GDF-8, myostatin) has been proposed for the management of adult heart failure (HF). Its potential role in pediatric HF patients is unknown. We sought to investigate its diagnostic performance in adult versus pediatric HF.METHODS:
GDF-8 was measured prospectively in pediatric and adult HF patients and in matching controls. HF was defined as the combination of typical symptoms and impaired left ventricular systolic function. Diagnostic performance for the detection of HF was evaluated by receiver operating characteristic (ROC) analysis.RESULTS:
We enrolled 137 patients with HF (85 pediatric) and 67 healthy controls (47 pediatric). Neither pediatric nor adult HF patients had significantly different GDF-8 levels compared to the reference groups (3.53 vs 3.46 ng/mL, p = 0.334, and 6.87 vs 8.15 ng/mL, p = 0.063, respectively), but pediatric HF patients had significantly lower GDF-8 levels compared to adult patients (p < 0.001). ROC analysis showed no significant improvement adding GDF-8 to NT-proBNP, age and sex (area under the curve (AUC) 0.870 vs 0.868, p = 0.614) in children and neither in addition to age nor sex in adult HF patients (AUC 0.74 vs 0.62, p = 0.110).CONCLUSION:
GDF-8 did not accurately differentiate between HF patients and normal comparators in neither adults nor in children.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Miostatina
/
Insuficiencia Cardíaca
Límite:
Adult
/
Child
/
Humans
Idioma:
En
Revista:
Clin Chim Acta
Año:
2024
Tipo del documento:
Article
País de afiliación:
Austria