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Discordant gene expression in subcutaneous adipose and skeletal muscle tissues in response to exercise training.
Svensson, Michael; Lovric, Alen; Åkerfeldt, Torbjörn; Hellsten, David; Haas, Tara; Gustafsson, Thomas; Rullman, Eric.
Afiliación
  • Svensson M; Department of Community Medicine and Rehabilitation, Section of Sports Medicine, Umeå University, Umeå, Sweden.
  • Lovric A; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
  • Åkerfeldt T; Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
  • Hellsten D; Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
  • Haas T; Faculty of Health, School of Kinesiology and Health Science, York University, Toronto, Canada.
  • Gustafsson T; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
  • Rullman E; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
Physiol Rep ; 12(7): e15995, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38561245
ABSTRACT
Exercise has different effects on different tissues in the body, the sum of which may determine the response to exercise and the health benefits. In the present study, we aimed to investigate whether physical training regulates transcriptional network communites common to both skeletal muscle (SM) and subcutaneous adipose tissue (SAT). Eight such shared transcriptional communities were found in both tissues. Eighteen young overweight adults voluntarily participated in 7 weeks of combined strength and endurance training (five training sessions per week). Biopsies were taken from SM and SAT before and after training. Five of the network communities were regulated by training in SM but showed no change in SAT. One community involved in insulin- AMPK signaling and glucose utilization was upregulated in SM but downregulated in SAT. This diverging exercise regulation was confirmed in two independent studies and was also associated with BMI and diabetes in an independent cohort. Thus, the current finding is consistent with the differential responses of different tissues and suggests that body composition may influence the observed individual whole-body metabolic response to exercise training and help explain the observed attenuated whole-body insulin sensitivity after exercise training, even if it has significant effects on the exercising muscle.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Obesidad Límite: Adult / Humans Idioma: En Revista: Physiol Rep Año: 2024 Tipo del documento: Article País de afiliación: Suecia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Obesidad Límite: Adult / Humans Idioma: En Revista: Physiol Rep Año: 2024 Tipo del documento: Article País de afiliación: Suecia