The Endo-Lysosomal Damage Response.
Annu Rev Biochem
; 93(1): 367-387, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38594929
ABSTRACT
Lysosomes are the degradative endpoints of material delivered by endocytosis and autophagy and are therefore particularly prone to damage. Membrane permeabilization or full rupture of lysosomal or late endosomal compartments is highly deleterious because it threatens cellular homeostasis and can elicit cell death and inflammatory signaling. Cells have developed a complex response to endo-lysosomal damage that largely consists of three branches. Initially, a number of repair pathways are activated to restore the integrity of the lysosomal membrane. If repair fails or if damage is too extensive, lysosomes are isolated and degraded by a form of selective autophagy termed lysophagy. Meanwhile, an mTORC1-governed signaling cascade drives biogenesis and regeneration of new lysosomal components to reestablish the full lysosomal capacity of the cell. This damage response is vital to counteract the effects of various conditions, including neurodegeneration and infection, and can constitute a critical vulnerability in cancer cells.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Endosomas
/
Autofagia
/
Transducción de Señal
/
Diana Mecanicista del Complejo 1 de la Rapamicina
/
Lisosomas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2024
Tipo del documento:
Article