Phenolic constituents from the branches of Viburnum chinshanense as potential α-amylase and α-glucosidase inhibitory agents.
Nat Prod Res
; : 1-7, 2024 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-38619012
ABSTRACT
This paper reports the isolation of two undescribed phenolic glycosides (1 and 2), together with seven known compounds (3-9) from the branches of Viburnum chinshanense. The structures of undescribed compounds were elucidated by comprehensive spectroscopic methods (1D NMR, 2D NMR, and HRESIMS). The sugar units of compounds 1 and 2 were identified by acid hydrolysis and HPLC analysis of the chiral derivatives of the monosaccharides. Furthermore, the αamylase and α-glucosidase inhibitory activities of all isolates were evaluated and compounds 1, 5, and 8 displayed potential αamylase and α-glucosidase inhibitory activities. The molecular docking analyses of compounds 1 and 8 with the potent inhibition towards the target enzymes were also performed.
Texto completo:
1
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Nat Prod Res
/
Nat. prod. res. (Online)
/
Natural product research (Online)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China