Synthesis of 2-Aryl Indazole: Synthesis, Biological Evaluationand In-Silico Studies.
Chem Biodivers
; 21(7): e202302085, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38666662
ABSTRACT
In this work, a highly effective synthesis technique for obtaining aryl indazole under mild circumstances is provided, using trimethyl phosphine as a powerful reagent. The procedure shows that a wide range of substrates can be investigated, yielding various 2-aryl indazole derivatives with acceptable to exceptional yields and a wide range of functional group tolerance. Additionally, based on Inâ
Silico studies tests were conducted to determine the anticancer activity Inâ
Vitro for all produced compounds (3 a-3 j) against A549, HT-29 and HepG2â
cell lines. Compoundsâ
3 c and 3 d, with IC50 values of 15, 53.55, 7.34, 7.10, 56.28, and 17.87 (µM) against A549, HT-29 and HepG2 respectively, showed significant anticancer activity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ensayos de Selección de Medicamentos Antitumorales
/
Proliferación Celular
/
Indazoles
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Chem Biodivers
/
Chem. biodivers. (Online)
/
Chemistry & biodiversity (Online)
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
India