Adipose tissue macrophage-derived microRNA-210-3p disrupts systemic insulin sensitivity by silencing GLUT4 in obesity.

Patra, Debarun; Ramprasad, Palla; Sharma, Shivam; Dey, Upalabdha; Kumar, Vinod; Singh, Satpal; Dasgupta, Suman; Kumar, Aditya; Tikoo, Kulbhushan; Pal, Durba

Patra, Debarun; Ramprasad, Palla; Sharma, Shivam; Dey, Upalabdha; Kumar, Vinod; Singh, Satpal; Dasgupta, Suman; Kumar, Aditya; Tikoo, Kulbhushan; Pal, Durba.

Afiliación

Patra D; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Ramprasad P; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India.
Sharma S; Department of Pharmacology and Toxicology, NIPER, S.A.S. Nagar, Punjab, India.
Dey U; Department of Molecular Biology & Biotechnology, Tezpur University, Tezpur, Assam, India.
Kumar V; Department of Pharmacology and Toxicology, NIPER, S.A.S. Nagar, Punjab, India.
Singh S; Department of Gastro Surgery, DMC&H, Ludhiana, Punjab, India.
Dasgupta S; Department of Molecular Biology & Biotechnology, Tezpur University, Tezpur, Assam, India.
Kumar A; Department of Molecular Biology & Biotechnology, Tezpur University, Tezpur, Assam, India.
Tikoo K; Department of Pharmacology and Toxicology, NIPER, S.A.S. Nagar, Punjab, India.
Pal D; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab, India. Electronic address: durba.pal@iitrpr.ac.in.

J Biol Chem ; 300(6): 107328, 2024 Jun.

Article en En | MEDLINE | ID: mdl-38679332

Asunto(s)

Transportador de Glucosa de Tipo 4; Resistencia a la Insulina; Macrófagos; MicroARNs; Obesidad; MicroARNs/genética; MicroARNs/metabolismo; Animales; Obesidad/metabolismo; Obesidad/genética; Obesidad/patología; Macrófagos/metabolismo; Ratones; Transportador de Glucosa de Tipo 4/metabolismo; Transportador de Glucosa de Tipo 4/genética; Masculino; Ratones Endogámicos C57BL; Tejido Adiposo/metabolismo; Tejido Adiposo/patología; Humanos; Dieta Alta en Grasa/efectos adversos; Intolerancia a la Glucosa/metabolismo; Intolerancia a la Glucosa/genética; Intolerancia a la Glucosa/patología; Vesículas Extracelulares/metabolismo; Vesículas Extracelulares/genética; Grasa Intraabdominal/metabolismo; Grasa Intraabdominal/patología

Palabras clave

GLUT4; adipose tissue microenvironment; extracellular vesicles; insulin resistance; miR-210-3p; obesity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / MicroARNs / Transportador de Glucosa de Tipo 4 / Macrófagos / Obesidad Límite: Animals / Humans / Male Idioma: En Revista: J Biol Chem Año: 2024 Tipo del documento: Article País de afiliación: India

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