Formal Synthesis of (+)-Sinefungin by Way of Sequential Asymmetric Metal Catalysis.
Org Lett
; 26(18): 3957-3960, 2024 May 10.
Article
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| MEDLINE
| ID: mdl-38683026
ABSTRACT
Here, we report a de novo approach toward (+)-sinefungin, a potent inhibitor of the physiological methyl transfer process. A key feature is represented by the sequential metal catalysis combining Pd-catalyzed hydroalkoxylation and ring-rearrangement metathesis. The unique advantage of the method is highlighted by the unprecedented complete control of the C6 stereocenter.
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article