Tf2O-Mediated P(O)-N Bond Formation of Either P(O)-OH or P(O)-H Reagents with Multitype Amines.
J Org Chem
; 89(10): 6729-6739, 2024 May 17.
Article
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| MEDLINE
| ID: mdl-38690961
ABSTRACT
We have developed a Tf2O-mediated approach for the direct amination of either P(O)-OH or P(O)-H reagents with a variety of aliphatic or aromatic amines. Without the requirement of precious metals and toxic reagents, this protocol provides an alternative route to various phosphinamides and phosphoramides. The reaction proceeds under simple and mild conditions and can be effectively scaled up with similar efficiency.
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MEDLINE
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Revista:
J Org Chem
Año:
2024
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Article