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The mitochondrial multi-omic response to exercise training across rat tissues.
Amar, David; Gay, Nicole R; Jimenez-Morales, David; Jean Beltran, Pierre M; Ramaker, Megan E; Raja, Archana Natarajan; Zhao, Bingqing; Sun, Yifei; Marwaha, Shruti; Gaul, David A; Hershman, Steven G; Ferrasse, Alexis; Xia, Ashley; Lanza, Ian; Fernández, Facundo M; Montgomery, Stephen B; Hevener, Andrea L; Ashley, Euan A; Walsh, Martin J; Sparks, Lauren M; Burant, Charles F; Rector, R Scott; Thyfault, John; Wheeler, Matthew T; Goodpaster, Bret H; Coen, Paul M; Schenk, Simon; Bodine, Sue C; Lindholm, Malene E.
Afiliación
  • Amar D; Stanford University, Stanford, CA, USA; Insitro, San Francisco, CA, USA.
  • Gay NR; Stanford University, Stanford, CA, USA.
  • Jimenez-Morales D; Stanford University, Stanford, CA, USA.
  • Jean Beltran PM; Broad Institute, Boston, MA, USA.
  • Ramaker ME; Duke University, Durham, NC, USA.
  • Raja AN; Stanford University, Stanford, CA, USA.
  • Zhao B; Stanford University, Stanford, CA, USA.
  • Sun Y; Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
  • Marwaha S; Stanford University, Stanford, CA, USA.
  • Gaul DA; Georgia Institute of Technology, Atlanta, GA, USA.
  • Hershman SG; Stanford University, Stanford, CA, USA.
  • Ferrasse A; Stanford University, Stanford, CA, USA.
  • Xia A; National Institutes of Health, Bethesda, MD, USA.
  • Lanza I; The Mayo Clinic, Rochester, MN, USA.
  • Fernández FM; Georgia Institute of Technology, Atlanta, GA, USA.
  • Montgomery SB; Stanford University, Stanford, CA, USA.
  • Hevener AL; University of California, Los Angeles, Los Angeles, CA, USA.
  • Ashley EA; Stanford University, Stanford, CA, USA.
  • Walsh MJ; Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
  • Sparks LM; Translational Research Institute AdventHealth, Orlando, FL, USA.
  • Burant CF; University of Michigan, Ann Arbor, MI, USA.
  • Rector RS; University of Missouri, Columbia, MO, USA.
  • Thyfault J; University of Kansas Medical Center, Kansas City, KS, USA.
  • Wheeler MT; Stanford University, Stanford, CA, USA.
  • Goodpaster BH; Translational Research Institute AdventHealth, Orlando, FL, USA.
  • Coen PM; Translational Research Institute AdventHealth, Orlando, FL, USA.
  • Schenk S; University of California, San Diego, La Jolla, CA, USA.
  • Bodine SC; Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
  • Lindholm ME; Stanford University, Stanford, CA, USA. Electronic address: malenel@stanford.edu.
Cell Metab ; 36(6): 1411-1429.e10, 2024 Jun 04.
Article en En | MEDLINE | ID: mdl-38701776
ABSTRACT
Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium mapped the temporal, multi-omic changes in mitochondrial analytes across 19 tissues in male and female rats trained for 1, 2, 4, or 8 weeks. Training elicited substantial changes in the adrenal gland, brown adipose, colon, heart, and skeletal muscle. The colon showed non-linear response dynamics, whereas mitochondrial pathways were downregulated in brown adipose and adrenal tissues. Protein acetylation increased in the liver, with a shift in lipid metabolism, whereas oxidative proteins increased in striated muscles. Exercise-upregulated networks were downregulated in human diabetes and cirrhosis. Knockdown of the central network protein 17-beta-hydroxysteroid dehydrogenase 10 (HSD17B10) elevated oxygen consumption, indicative of metabolic stress. We provide a multi-omic, multi-tissue, temporal atlas of the mitochondrial response to exercise training and identify candidates linked to mitochondrial dysfunction.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Mitocondrias Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Mitocondrias Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos