Synthesis of Diverse Allylic Sulfone Derivatives via Sequential Hydroalkoxylation of 1,3-Enynes.
Chemistry
; 30(42): e202401049, 2024 Jul 25.
Article
en En
| MEDLINE
| ID: mdl-38712686
ABSTRACT
A first metal-free protocol for the synthesis of allylic sulfones featuring aldehyde functionality at the δ-position has been reported. The formation of structurally complex δ,δ-dimethoxy allylic sulfones is enabled by the direct nucleophilic attack of methoxide onto the sulfone-containing 1,3-enynes. The present approach allows facile installation of acetal groups within the allylic sulfone scaffold, providing versatile platforms for further functionalization and drug development.
Texto completo:
1
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
India